Daniel was born in Ludlow in 1839. He matriculated in Black River Academy in 1858 but interrupted his studies to volunteer for the Civil War, where he was wounded, taken prisoner, and exchanged. He returned to B. R. A. and met Miss Alice Viola Marsh born in Plymouth in 1847. Viola said they fell in love, then Daniel began medical school at UVM, and they married in 1866. She was excited to experience New York City during his residency at Bellevue Medical. Dr. Cooledge opened a Ludlow medical practice in 1868. Later, the Cooledges opened a drug store on Main Street. Viola assisted in the store while raising five children. She became the first woman registered pharmacist in Vermont, and following her husband’s death in 1911, she managed the store herself until her death in 1934 at the age of 87. The store kept the Cooledge name for 75 years.